FedEx is working with Reliable Robotics to pilot the use of an unmanned single-engine aircraft for cargo delivery.
FedEx CEO Fred Smith announced details of the collaboration earlier this week.
"This initiative deals with smaller turboprop airplanes and in this case the single-engine C208, which we are looking at putting in very remote and uninhabited areas as part of our network," he said.
However, Mr Smith said company does not intend to replace its current aircraft fleet with autonomous alternatives.
“Crews should not be worried about the technology for the foreseeable future – decades, I would say."
Last month, Reliable Robotics completed test flights of two remote-piloted aircraft models.
"In the first flight, the pilot pressed a button on a remote user interface and the unmanned four passenger Cessna 172 Skyhawk (C172) automatically taxied, took off, and landed," the company said in a recent media release.
"Most recently, the company demonstrated fully automated remote landing of an even larger aircraft, the Cessna 208 Caravan (C208), capable of carrying 14 passengers."
FedEx is listed as the registered owner of the Cessna 208 shown in Reliable Robotics' media release.
Reliable Robotics said it is working with the Federal Aviation Administration (FAA) in the US on “incrementally bringing this technology to market."
And it is not the only aviation company thinking about creating flying autonomous delivery options that can hold more than the drones currently making their way to market.
Elroy Air hasn't made full Cessnas autonomous, but its drone can carry payloads of up to 225kg, according to its website.
FedEx's work with Reliable Robotics is just part of the effort to automate aspects of the supply chain.